Fig. 1. Behavioral and electrographic changes observed during status epilepticus (SE). In A, significant differences in the duration of stage (st.) 4 and 5 convulsive seizures were determined during 12 h after the administration of kainic acid (KA). In B, a relative indication of distribution of power over the frequency, expressed in percentage, was determined during 12 h after the administration of the KA. In C, a linear regression (r²) between the gamma power at 30 min after the administration of KA, and the total duration of SE is illustrated. In D, the position of frontal and occipital electrodes is shown. In E, the development and evolution of SE in the KA model were reported. Particularly, the baseline and then the first nonconvulsive seizure is represented in E.I. The progression from nonconvulsive SE to convulsive SE is reported in E.II. The evolution of SE over time is represented in E.III. The interictal spikes appearing at the end of SE and then the return to baseline are reported in E.IV. Statistical analysis was performed using a one-way repeated measures analysis of variance (ANOVA) followed by multiple comparisons versus control group (Dunnett's test). Data are shown as mean ± SEM. ° p<0.05 (st. 4), * p<0.05 (st. 5), # p<0.05 (st. 4 + 5); Scale: 0.5 mV/5 s. LFC, left frontal cortex; LOC, left occipital cortex; Ref, reference electrode; RFC, right frontal cortex; ROC, right occipital cortex.